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1994-10-25
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Document 3225
DOCN M94A3225
TI The role of nitric oxide in patients with HIV-1 infection.
DT 9412
AU Torre D; Ferrario G; Bonetta G; Zeroli C; Giola M; Fiori GP; Div.
Infectious Diseases, Varese, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):124 (abstract no. PA0114). Unique
Identifier : AIDSLINE ICA10/94369350
AB OBJECTIVE: Nitric oxide (NO) and its intermediates, nitrite and nitrate,
exert microbiostatic and microbicidal effects against protozoa, fungi,
bacteria and some viruses, including herpes simplex virus. NO modulates
immune responses by mediating the regulation of lymphocyte proliferation
and it influences local inflammatory reactions by altering adherence of
neutrophils to endothelial surfaces. METHODS: Serum and bronchoalveolar
lavage fluid levels of nitrite were measured colorimetrically by the
Griess reaction, the absorbance was read at 550 nm. Data are expressed
as micromoles of nitrite/liter. RESULTS: Normal levels of NO was noted
in the sera of asymptomatic seropositive patients, in patients with
HIV-1 encephalopathy, with cryptococcal meningitis, and in those with
lymphoma. In contrast, increased levels of NO were noted in the sera
(26.1 +/- 23.7 mumol/L; P < .0001) and in the bronchoalveolar lavage
fluid (0.2 +/- 0.3 mumol/L; P = .0071). DISCUSSION AND CONCLUSIONS: It
is likely that NO is produced in the lung during different processes,
including host defense. NO may play a role in pulmonary cell-to-cell
interactions and critical defense mechanisms of the host, in particular
against opportunistic pathogens such as Pneumocystis carinii and
Micobacterium sp.
DE Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/ *METABOLISM
AIDS Dementia Complex/BLOOD AIDS-Related Opportunistic Infections/BLOOD
Bronchoalveolar Lavage Fluid/CHEMISTRY Comparative Study Human HIV
Seropositivity/BLOOD *HIV-1 Lymphoma/BLOOD/COMPLICATIONS Meningitis,
Cryptococcal/BLOOD Nitric Oxide/ANALYSIS/BLOOD/*PHYSIOLOGY
Nitrites/ANALYSIS Reference Values Spectrophotometry/METHODS MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).